The purpose of this experiment was to determine the rate of dissolution
for different brands of Ibuprofen.
I became interested in this idea when I had a headache and took an
Advil and I decided that it would be a good idea to see which brand
would cure my headache the fastest.
The information gained from this experiment could benefit every person
that has had a headache and didn’t get the fastest relief possible. I
think that everyone has the need to get his or her headaches relieved
as soon as possible.
My hypothesis was that the roughest and smallest pill would dissolve
I based my hypothesis on the fact that the smallest and roughest pill
would break up the quickest because it isn’t as well compacted as the
The constants in this study were:
- Amount of water (250ml) for each test
- Temperature of water (37∞ Celsius)
- Speed of magnetic stirrer (high setting)
- Type of water (tap)
- Amount of pills (one) tested at one time
- Testing procedures
- Type of stopwatch
- Type of pill (Ibuprofen)
The manipulated variable was the brand of Ibuprofen.
The responding variable was the dissolution time.
To measure the responding variable I used a stopwatch accurate to 0.01.
|Ibuprofen for each of the
| 300 ml glass beakers
| pair of heat
|| thick lab apron
1. Measure 250ml of tap water
2. Pour 250ml of water into a microwave safe container
3. Heat water in microwave to 37∞ Celsius
4. Pour heated water into 300 ml glass beaker (Only up to the 250 mark
5. Put onto magnetic stirrer’s base
6. Drop in magnetic stirring capsule
7. Turn on magnetic stirrer to high (Let the stirrer get going fast
before you drop in the pill)
8. Drop in first brand of Ibuprofen pill
9. Immediately Start stopwatch
10. When the pill dissolves (disappears) stop the stop watch then the
11. Record the dissolution time of the pill in minutes and seconds
12. Repeat steps 1-11 for the other pills of this same brand (5 more
13. Repeat steps 1-12 using the next brand of pills
14. Repeat steps 1-13 with the remaining brands
15. Average the dissolution rate for each brand.
16. Compare brands
The original purpose of this experiment was to determine the
Dissolution rate of different brands of Ibuprofen.
The results of the experiment were that the brand Advil had the fastest
table and graph
My hypothesis was that the smallest and smoothest pill would dissolve
the quickest because it is the smallest.
The results indicate that this hypothesis should be accepted.
Because of the results of this experiment, I wonder if I compared the
rate of dissolution of lactase pills and Advil pills and see which one
would dissolve the quickest.
If I were to conduct this project again I would try seeing if different
temperatures of water had any effect on the dissolution rate.
I would like to thank the following people for helping make my project
Pain pills are important to everyone. In order to get the best cure for
pain like a headache, one needs the fastest dissolving pill. The faster
a pill dissolves the faster it will get in the system and help with
whatever problem exists.
Dissolution is the act or process of breaking up into parts or
disintegration. A pill can use the act of dissolution because it will
break up into tiny particles not just stay all together.
A solvent is a liquid that is capable of dissolving another substance.
Something that is a solvent is water. Water is a solvent because it can
dissolve things like Ibuprofen. Many other liquids are solvents as
well. Soluble means capable of being dissolved. Soluble things are also
called solutes. An Ibuprofen pill is a solute because it is capable of
being dissolved. Other types of pills are also solutes because they can
Rate is a measured quantity that occurs or is attained within the
limits of a fixed quantity. In this project you would use rate to write
down the time in which the pills dissolved. Rate is also used in many
different experiments like if someone was going to measure how fast
somebody else ran you could say the rate that they ran was two miles
Ibuprofen is a type of drug used to dull pain in an area that is hurt.
For example if someone where to go running and their leg muscles were
hurting them then it would be a great idea for that person to take
Ibuprofen so that they will feel better. A few health issues have been
linked to pain relievers. The most serious of the health issue is a
heart attack. Health authorities are now reviewing dozens of studies,
including popular brands like aspirin and Advil.
Ibuprofen bad for hearts
Aspirin and other older painkillers block two enzymes, Cox-1 and Cox-2
that are involved in inflammation and pain. Now main drugs only block
Cox-2. Which still isn’t great because if Cox-1 isn’t blocked off then
the aspirin isn’t helping the heart. However because Cox-2 isn’t
blocked off then it lowers the risk of gastrointestinal problems.
Pain relievers are taken to relieve different types of pain or
discomfort. Some people may think pain is a disease, but it’s not it is
only a symptom. Nonprescription pain relievers are analgesics that one
doesn’t require a doctor’s prescription.
Anesthetics are drugs that are taken to deaden feeling. The first
synthetic local anesthetic was procaine, better remembered today by its
trade name, "Novocain". Novocain had a lot of problems. For example it
didn’t dry fast enough, it was as potent as cocaine and it wore off too
quickly. About one third of the people that took Novocain ended up with
at least a minor allergic reaction. Today procaine isn’t even available
in dentist’s offices.
Even though there are many different problems with Ibuprofen. Now
everyone can use the fastest acting pain reliever to get rid of their
headaches, stomach aches, sore muscles or any other type of pain.
Deseret News. “All Drugs Have Risks; Here Are the Facts on
“Dissolving.” Young Scientist pp.19–21.
National Cancer Institute, “Nonprescription Pain Relievers,”
“Ibuprofen” World Book Encyclopedia, 1998.
Spiller, Martin, D.M.D. “Local Anesthetics,
- My Mom and my sister for helping me organize my papers in a
way that was easy to understand.
- My friend Brooke for encouraging me to keep
persevering when I thought my project got too hard.
- Mr. Newkirk for helping me edit my project to make
- Mrs. Helms for always answering any of my questions if I
ever had any.
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